Pyridoxine-responsive Anemia: Influence of Tryptophan on Pyridoxine Responsiveness

Pyridoxine-responsive anemia: influence of tryptophan on pyridoxine responsiveness.

This study presents evidence that the indolic amino acid, tryptophan, critically influences pyridoxine responsiveness in a patient with pyridoxine-responsive anemia. Continuing observations for 18 yr on this now 54-yr-old white man have shown responsiveness to oral crude liver extract and to pyridoxine. In addition, remissions of 8-mo duration followed oral administration of fractions of liver ...

Pyridoxine-responsive anemia.

SI NCE THE ORIGINAL report by Harris et al.' in 1956, six additional I)ttients with anemia responsive to the administration of pyrinioxine have been described.27 With the exception of the case reported by Maier,2 tile features which have been common to this group of patients hiave I)een micro-cytic, hypochromic anemia, hyperferremia, hemosidlerosis and a partial or complete response of the anem...

Pyridoxine responsive epilepsy: expanded pyridoxine dependency?

Pyridoxine-responsive anemia conditioned by isonicotinic acid hydrazide.

S INCE THE FIRST report in 1956 of a patient with pyridoxine-responsive anemia, a number of other patients have been reported.”2 The red blood cells usually are hypochromic and microcytic but occasionally they may be macrocytic and accompanied by megaboblastic bone marrow maturation. It is unlikely that many of these patients have a simple dietary deficiency of pyridoxine, since barge doses of ...

Porphyrin synthesis and heme synthetase activity in pyridoxine-responsive anemia.

T HE RATE OF HEME SYNTHESIS was found to be reduced in a patient with pyridoxine-responsive anemia ( PRA ) . The incubation of reticulocytes with glycine-2-14C or -aminolevulinic acid-4-14C (ALA) resulted in labeling of hemin derived from hemoglobin. PRA reticulocytes incorporated glycine into heme at 11-25 per cent of the normal rate. ALA incorporation varied from 46 to 81 per cent of normal. ...